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| Catalog Code: | NB100-78506 |
| Product Name: | GCN2 Antibody |
| Product Description: | Rabbit Polyclonal anti-GCN2 |
| Clonality: | Polyclonal |
| ListPrice: | 340 |
| Immunogen: | Recombinant partial protein corresponding to a.a.120-330 of human GCN2 |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | This rabbit polyclonal antibody recognizes human GCN2 also known as Eukaryotic translation initiation factor 2 alpha kinase 4, EIF2AK4, GCN2 eIF2alpha kinase and KIAA1338. GCN2 is a ubiquitously expressed cytoplasmic protein, contains a larger region adjacent to the protein kinase domain that is similar in sequence to histidyl-tRNA synthetases(HisRSs), predicted molecular weight approximately 92 kD. GCN2 belongs to a family of stress-responsive protein kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 to regulate general and gene-specific protein synthesis under various cellular stress conditions. GCN2 has been shown to interact with eIF2? protein. The poly6304 antibody has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Eukaryotic translation initiation factor 2 alpha kinase 4 antibody, anti-EIF2AK4 antibody, anti-GCN2 eIF2alpha kinase and KIAA1338 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Berlanga, J. J., et al. 1999. Europ. J. Biochem. 265:754.2. Costa-Mattioli, M., et al. 2005. Nature 436:1166. |
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