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| Catalog Code: | NB100-78468 |
| Product Name: | Eg5 Antibody |
| Product Description: | Mouse Monoclonal anti-Eg5 (10C7/Eg5), conjugated to Biotin |
| Clone: | 10C7/Eg5 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Amino Acid: 200-500 of human Eg5 |
| Cross Reactivity: | Human, Mouse. |
| Packaging: | 0.25 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 mug antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Eg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. This protein is a catalytic kinesin motor with coiled-coil and Smc domains. Eg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. This motor protein is required for establishing the bipolar spindle. hEg5 is modified by phosphorylation on Thr927 by Cdc2 to allow association with the spindle apparatus. Eg5 has been shown to interact with the thyroid hormone receptor in presence of thyroid hormone and Cdc2. The 10C7/Eg5 monoclonal antibody has been shown to react with human and mouse Eg5 by Western blot. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| Application Summary: | immunofluorescence, Western Blot |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-Kinesin-like protein KIF11 antibody, anti-kinesin-related motor protein Eg5 antibody, anti-kinesin-like spindle protein HKSP antibody, anti-thyroid receptor interacting protein 5 (TRIP5) antibody |
| Package Size: | 0.25 mg |
| Conjugate: | Biotin |
| General References: | 1. Lee, J., et al., 1995. Mol. Endocrinol. 9:243. 2. Blangy, A., et al., 1995. Cell 83:1159. 3. Whitehead, C., et al., 1998. J. Cell Sci. 111:2551. 4. DeBonis, S., et al., 2003. Biochemistry. 42:338. |
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