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| Catalog Code: | NB100-78463 |
| Product Name: | PARC Antibody |
| Product Description: | Mouse Monoclonal anti-PARC (PO69) |
| Clone: | PO69 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Human PARC peptide, corresponding to human amino acids AWEAKGPNMPGSC |
| Cross Reactivity: | Human, mouse. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5 mug per 5 ml antibody dilution buffer (1:500 dilution) for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | The PARC protein, also known as p53-associated parkin-like cytoplasmic protein and UbcH7 associated protein 1, is a large ( gt250 kD) ubiquitously expressed cytoplasmic protein that contains a cullin domain and signature RING-IBR (in-between ring finger domain)-RING domains. PARC is thought to serve as a cytoplasmic anchor in p53-associated complexes thought to be critical in controlling p53 subcellular localization and function. These large complexes that contain PARC, p53 and other associated proteins are approximately 1 MD in non-stressed cells. The PARC protein has been shown to interact with a number of proteins including p53, UBCH8, ubiquitin conjugating enzyme E2G2, and ubiquitin conjugating enzyme E2L3. The P069 monoclonal antibody recognizes human PARC and has been shown to be useful for Western blotting. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-p53-Associated Parkin Like Cytoplasmic Protein antibody, anti-UbcH7 associated protein 1 antibody, anti-H7AP1 antibody, anti-H7/AP1 antibody, anti-KIAA0708 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Nikolaev, A. Y., et al., 2003. Cell 112:29.2. Nikolaev, A.Y., and Gu, W. 2003. Cell Cycle 2:169.3. Skaar, J. R., et al., 2005. Mol. Cell. Biol. 25:5579. |
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