| CatalogCode: | NB100-78460 |
| ProductName: | STAT 1 Antibody |
| Product Description: | Mouse Monoclonal anti-STAT 1 (SAT-84) |
| Clone: | SAT-84 |
| Clonality: | Monoclonal |
| Immunogen: | STAT1 peptide QLDSKFLEQVHQLYD |
| CrossReactivity: | Human. |
| Packaging: | 0.1 mg protein G purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 mug per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Ubiquitous cytoplasmic expression |
| Background: | STAT1, also known as signal transduction and activator of transcription-1, is a ubiquitously expressed cytoplasmic protein that becomes phosphorylated in response to cytokine signaling (interferon alpha, interferon gamma, EGF, PDGF, and IL-6) by receptor-associated kinases and translocates to the nucleus to act as a transcriptional activator. Two isoforms of STAT1 exist as a result of alternative RNA processing with apparent molecular weights of 88 and 91 kD. STAT1 has been shown to interact with a number of proteins including STAT3, FAK, MCM3, MCM5, TRADD, BRCA1, KIT, IL-27 receptor, IL-2R beta and gamma, IFN alphaR beta, STAT2, c-Src, and many others. STAT1 knockout mice are highly sensitive to infection with microbial infections and viruses. The SAT-84 monoclonal antibody recognizes human STAT1 and has been shown to be useful for Western blotting. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG1, kappa |
| Host_Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| ListPrice: | 325 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Signal transduction and activator of transcription-1 antibody, anti-STAT-1 antibody |
| ProteinTarget: | STAT 1 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Durbin, J. E., et al., 1996. Cell 8:443.2. Darnell, J. E., Jr., et al., 1994. Science 264:1415.3. Chen, X., et al., 1998. Cell 93:827.4. Ramana, C. V., et al., 2000. Oncogene 19:2619. |
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