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| Catalog Code: | NB100-78459 |
| Product Name: | TRIM Antibody |
| Product Description: | Mouse Monoclonal anti-TRIM (TRIM-4) |
| Clone: | TRIM-4 |
| Clonality: | Monoclonal |
| ListPrice: | 325 |
| Immunogen: | Partial recombinant human TRIM (amino acids 29-186) |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg protein G purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 mug per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | TRIM is a 30 kD disulfide-linked protein also known as T cell receptor interacting molecule. TRIM is a type III membrane protein containing a very short extracellular domain (8 amino acids). TRIM is highly expressed in T cells with some expression also observed in NK cells. TRIM is a signaling adaptor molecule that links extracellular and intracellular signaling. The TRIM protein is phosphorylated by Src kinases and associates with the PI3K regulatory subunit alpha after phosphorylation. TRIM has also been shown to associate with TCR alpha, beta, and ?. The TRIM-4 monoclonal antibody recognizes human TRIM and has been shown to be useful for Western blotting, intracellular staining by flow cytometry, and immunofluorescence staining. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | Immunocytochemistry, flow cytometry / FACS analysis, immunofluorescence, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-T cell receptor-interacting molecule antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Bruyns, E., et al., 1998. J. Exp. Med. 188:561.2. Hubener, C., et al., 2000. Immunogenetics 51:154. |
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