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| Catalog Code: | NB100-78454 |
| Product Name: | SOCS3 Antibody |
| Product Description: | Mouse Monoclonal anti-SOCS3 (SOC-25) |
| Clone: | SOC-25 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Full-length SOCS3 recombinant protein |
| Cross Reactivity: | Human, Mouse. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. For Western blotting, suggested working dilution(s): Use 5 mug per 5 ml antibody dilution buffer (1:500 dilution) for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | The SOCS3 (suppressor of cytokine signaling-3) protein is a 25 kD cytoplasmic protein that contains a SOCS box and an SH2 domain. SOCS3 has been shown to be involved the negative regulation of cytokine signaling via JAK/STAT pathway. SOCS3 has been shown to inhibit IL-2, IL-3, IL-4, IL-6, erythropoietin, prolactin, and growth hormone. SOCS3 has also been shown to regulate erythropoiesis in the fetal liver. SOCS3 is induced induced by inflammation, erythropoietin, GM-CSF, IL-10, and IFN- gamma. SOCS3 can be modified by JAK phophorylation which destabilizes the protein and ubiquitination which targets for destruction by the proteosome. SOCS3 has been shown to interact with the IGF-1 receptor, insulin receptor, gp130 receptor, erythropoietin receptor, leptin receptor, LIF receptor, JAK2, and elongin C. The SOC-25 monoclonal antibody recognizes human and mouse SOCS3 and has been shown to be useful for Western blotting. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0 |
| Application Summary: | Western Blot |
| Species Summary: | Hu, Mu |
| Alternate Names: | anti-Suppressor of cytokine signaling-3 |
| Package Size: | 0.1 mg |
| General References: | 1. Minamoto, S., et al., 1997. Biochem. Biophys. Res. Commun. 237:79. 2. Marine, J., et al., 1999. Cell 98:617. 3. Egwuagu, C., 2002. J Immunol. 168:3181. 4. Sasaki, A., et al., 2003. J. Biol. Chem. 278:2432. |
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