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| Catalog Code: | NB100-78446 |
| Product Name: | Nod2 Antibody |
| Product Description: | Mouse Monoclonal anti-Nod2 (NOD-15) |
| Clone: | NOD-15 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant human NOD2 |
| Cross Reactivity: | Human Nod2, does not cross-react with Nod1. |
| Packaging: | 0.1 mg protein G purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 microgram antibody per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Nod2, also known as caspase recruitment domain-containing protein 15, CARD15, and inflammatory bowel disease protein 1, is a monocyte-specific cytoplasmic protein containing two N-terminal caspase recruitment domains (CARD domains), and multiple leucine-rich repeats with a predicted molecular weight 115 kD. Alternative initiation produces two isoforms of Nod2. Nod2 is thought to confer responsiveness to intracellular bacterial lipopolysaccharide (LPS), and defects in Nod2 have been linked to several diseases including Blau syndrome, Crohns's disease, and ulcerative colitis. Knock-out animals has been shown to have dramatically altered responses to bacterial pathogens in the gut. Nod2 binds to the receptor interacting kinase 1 protein via CARD-CARD interaction and induces NF- kappaB and IKK-gamma. The NOD-15 monoclonal antibody recognizes the human Nod2 protein and has been shown to be useful for Western blotting. The NOD-15 antibody does not cross-react with human Nod1. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | protein G purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Caspase recruitment domain-containing protein 15 antibody, anti-CARD15 antibody, anti-inflammatory bowel disease protein 1 |
| Package Size: | 0.1 mg |
| General References: | 1. Ogura, Y., et al., 2001. J. Biol. Chem. 276:4812.2. Hugot, J.-P., et al., 2001. Nature 411:599.3. Miceli-Richard, C., et al., 2001. Nat. Genet. 29:19.4. Kobayashi, K. S., et al., 2005. Science 37:731. |
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