| CatalogCode: | NB100-78445 |
| ProductName: | hnRNP K-Methylated Antibody |
| Product Description: | Rabbit Polyclonal anti-hnRNP K-Methylated [Lys21] |
| Clonality: | Polyclonal |
| Immunogen: | Modified peptide |
| CrossReactivity: | Human, reacts with Lys219-methylated hnRNP K. |
| Packaging: | 0.05 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Ubiquitously expressed cytoplasmic and nuclear protein |
| Background: | hnRNP K (also known as heterogeneous nuclear ribonucleoprotein K, DC-stretch binding protein, and transformation upregulated protein (TUNP)) is a 51 kD heterogenous nuclear ribonucleoprotein family containing KH domains. This protein is ubiquitously expressed in the cytoplasm and the nucleus. hnRNP K is a pre-mRNA binding protein and a component of hnRNP complexes providing substrate for pre-mRNA processing before becoming translatable mRNAs in cytoplasm. hnRNP K acts as transcriptional regulator and functions in nucleocytoplasmic shuttling. hnRNP K expression and function are increased by epidermal growth factor (EGF). hnRNP K is modified by phosphorylation (PKC delta, c-Src) and acetylation. hnRNP K interacts with Csk, NCK2, Vav1, ITK, CEBP beta, c-Src, Fyn, Lyn, and Hepatitis virus core protein. The Poly6253 antibody recognizes human methylated hnRNP K (Lys219) and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Heterogeneous nuclear ribonucleoprotein K antibody, anti-DC-stretch binding protein antibody, anti-Transformation upregulated protein (TUNP) antibody |
| ProteinTarget: | hnRNP K-Methylated |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Matunis, M. J., et al., 1992. Mol. Cell. Biol. 12:164. 2. Dejgaard, K., et al., 1994. J. Mol. Biol. 236:33. 3. Mandal, M., et al., 2001. J. Biol. Chem. 276:9699 |
| Phosphorylated: | Lys21 |