| CatalogCode: | NB100-78444 |
| ProductName: | STAT 6 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT 6 |
| Clonality: | Polyclonal |
| Immunogen: | Peptide derived from the carboxy terminus of human STAT6 |
| CrossReactivity: | Human, Mouse, Rat. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Translocates into nucleus after phosphorylation. Expressed in olfactory, bronchial epithelium, adren |
| Background: | STAT 6 is an 94 kD member of the STAT (signal transducer and activator of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT 6 induces nuclear translocation to activate transcription. STAT 6 is expressed in olfactory cells, bronchial epithelium, adrenal gland, B cells, mast cells, Wilm's tumors and some solid tumors. STAT 6 forms homo- and heterotrimers and has been shown to be important in IL-4 mediated biological responses, the induction of Bcl-2 and Bcl-XL, and may also be involved in TH2 differentiation and immunoglobulin class switching. STAT 6 is phosphorylated in response to IL-4, IL-13, IL-3 and has been shown to interact with nuclear coactivator 1 (NCOA1), the CREB binding SRC-1 protein, and p300/CBP. The Poly6252 antibody recognizes the C-terminal region of human, mouse, and rat STAT6 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide, 50% |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Signal transducer and activator of transcription 6 antibody, anti-stat-6 antibody |
| ProteinTarget: | STAT 6 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Hou, J., et al., 1994. Science 265:1701. 2. Takeda, K., et al., 1996. Nature 380:627. 3. Carson, R., et al., 1996. Nature 380:630. |
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