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| Catalog Code: | NB100-78439 |
| Product Name: | Sp3 Antibody |
| Product Description: | Rabbit Polyclonal anti-Sp3 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Peptide mapping to the carboxy terminus of human Sp3 |
| Cross Reactivity: | Mouse, Rat, Human. |
| Packaging: | 0.5 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 25 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | The sequence-specific transcription factor Sp3 binds GC and GT box sequences in the promoters of a variety of genes. The Sp3 transcription factor contains three zinc finger domains that determine sequence specificity of DNA binding. This transcription factor is thought to regulate nucleoside, nucleotide and nucleic acid metabolism and many other housekeeping genes. Sp3 can be modified by sumoylation by Ubc9 and has been shown to interact with other transcription factors and histonbe deacetylases. Sp3 has been reported to act as a transcriptional enhancer and repressor of Sp1 activity in a cell- and context-dependent manner. The Poly6248 antibody recognizes the C-terminal region of human, mouse, and rat Sp3 and has been shown to be useful for Western blotting. |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Mu, Rt, Hu |
| Alternate Names: | anti-Transcription factor Sp3 antibody |
| Package Size: | 0.5 ml |
| General References: | 1. Liang, Y., et al. 1996. J. Biol. Chem. 271:11792.2. Hagen, G., et al. 1994. EMBO J 13:3843.3. Hagen, G., et al. 1992. Nucleic Acids Res. 20:5519. |
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