| CatalogCode: | NB100-78437 |
| ProductName: | STAT 3 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT 3 |
| Clonality: | Polyclonal |
| Immunogen: | Peptide mapping to the carboxy terminus of mouse STAT3 p92 |
| CrossReactivity: | Human, mouse, rat (does not react with STAT3b). |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Translocates into nucleus after phosphorylation. Expressed in brain, heart, placenta, lung, liver, s |
| Background: | STAT 3 is an 88 kD member of the STAT (signal transducer and activators of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT 3 induces nuclear translocation to activate transcription. STAT3 is expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. STAT 3 forms both homo- and heterotrimers and is involved in the activation of genes required for cell growth and apoptosis. STAT 3 is also involved in gp130 signaling and binds to IL-6 response elements in various acute phase protein promoters. STAT 3 is phosphorylated by signaling from IFNs, EGF, FGF, IL-5, HGF, LIF, and BMP2. STAT 3 activity is inhibited by PIAS3 and GRIM-19 and can also be regulated by Rac1 protein. STAT 3 interacts with Rac1, STAT 1, and NCOA1 proteins. The Poly6246 antibody recognizes the C-terminal region of human, mouse, and rat STAT3 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry. The Poly6246 antibody does not react with STAT3b. |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu, Rt |
| ALTnames: | anti-Signal transducer and activator of transcription 3 antibody, anti-stat-3 antibody |
| ProteinTarget: | STAT 3 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Lufei, C., et al., 2003. EMBO J. 22:1325. 2. Deo, D., et al., 2002. J. Biol. Chem. 277:21237. 3. Pfeffer, L., et al., 1997. Science 276:1418. 4. Akira, S., et al., 1994. Cell 77:63. |
|