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| Catalog Code: | NB100-78436 |
| Product Name: | STAT 2 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT 2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Peptide mapping to the carboxy terminus of human STAT2 |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. Immunohistochemistry-frozen/paraffin. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | STAT2, a 113 kD member of the STAT (signal transducer and activators of transcription) protein family, is phosphorylated in response to interferon alpha receptor signaling by Janus kinase I. Phosphorylation of STAT 2 induces nuclear translocation to activate transcription. STAT2 is highly expressed in the skin and thymus. STAT 2 forms complex with STAT1 and p48 to activate transcription and does not bind DNA directly. STAT 3 interacts with interferon regulatory factor 9, interferon alpha receptor, STAT 1, p48, and CREB binding protein. The Poly6245 antibody recognizes the C-terminal region of human STAT2 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry. |
| Storage: | Store at 4C. Do not freeze. DO NOT FREEZE. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Signal transducer and activator of transcription 2 antibody, anti-interferon alpha induced transcriptional activator antibody, anti-STAT-2 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Bluyssen, H. A. R., et al. 1997. J. Biol. Chem. 272:4600.2. Qureshi, A. A., et al. 1996. Mol. Cell. Biol. 16:288. |
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