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| Catalog Code: | NB100-78433 |
| Product Name: | ERK2 Antibody |
| Product Description: | Rabbit Polyclonal anti-ERK2 |
| Clonality: | Polyclonal |
| ListPrice: | 325 |
| Immunogen: | Peptide mapping to the carboxy terminus of rat ERK2 |
| Cross Reactivity: | Rat, Human, Mouse. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. Immunohistochemistry-frozen/paraffin. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | ERK2 is a 42 kD dual specificity kinase also known as mitogen activated protein kinase 1, extracellular signal regulated kinase 2, MAPK1, and p41mapk. The MAPK family includes several subgroups encompassing the ERK, JNK, and p38 kinases. ERK is phosphorylated in response to various extracellular signals inducing homodimerization and nuclear translocation where it phosphorylates target proteins regulating cell growth and survival. ERK2 interacts with a number of proteins including STAT5A, estrogen receptor alpha, ELK1, MEK1, protein kinase c epilson, RAF1, ribosomal S6 kinase, VAV1, STAT5b, Shc and many others. The Poly6242 antibody recognizes human, mouse, and rat ERK2 and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide, 50% |
| Application Summary: | immunohistochemistry, immunoprecipitation, Western Blot |
| Species Summary: | Rt, Hu, Mu |
| Alternate Names: | anti-Mitogen activated protein kinase 1 antibody, anti-extracellular signal regulated kinase 2 antibody, anti-MAPK1 antibody, anti-p41mapk antibody, anti-p42 MAP Kinase antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Khokhlatchev, A.V., et al. 1998. Cell 93:605.2. Boulton, T.G., et al. 1991. Cell 65:663. |
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