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| Catalog Code: | NB100-78431 |
| Product Name: | Paxillin Antibody |
| Product Description: | Mouse Monoclonal anti-Paxillin (PAX227) |
| Clone: | PAX227 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant full length |
| Cross Reactivity: | Mouse, Human. |
| Packaging: | 0.2 ml protein G purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. For immunofluorescence microscopy: Use a dilution range of 1:100~1:400. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Paxillin (also known as peroxisomal membrane protein 3) is a cytoplasmic protein with LIM metal-binding repeat homology and LIM domains. There are three isoforms of this protein designated as alpha, beta, gamma; approximate molecular weight 68 kD. Paxillin is localized to actin-membrane attachment at sites of cell adhesion to extracellular matrix (focal adhesion). This protein undergoes cell adhesion-dependent tyrosine phosphorylation. Paxillin has been shown to interact with FAK, vinculin, src, Crk, p210BRC / ABL, talin, and integrin- beta1. The PAX227 monoclonal antibody recognizes human and mouse paxillin and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein G purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | immunofluorescence, Western Blot |
| Species Summary: | Mu, Hu |
| Alternate Names: | anti-Peroxisomal membrane protein 3 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Leventhal, P., et al., 1997. J. Biol. Chem. 272:5214. 2. Mazaki, Y., et al., 1997. J. Biol. Chem. 272:7437. 3. Kirchner, J., et al., 2003. J. Cell Sci. 116:975. 4. Tang, D., et al., 2003. J. Physiol. 42:858. |
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