| CatalogCode: | NB100-78429 |
| ProductName: | T-bet Antibody |
| Product Description: | Rabbit Polyclonal anti-T-bet |
| Clonality: | Polyclonal |
| Immunogen: | Peptide-KLH |
| CrossReactivity: | Human, Mouse. |
| Packaging: | 0.05 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 5 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Nuclear; expressed in T cells, hematopoietic stem cells, NK cells, B cells, lung, spleen |
| Background: | T-bet, also known as T-box transcription factor T-bet, is considered to be a master regulator of Th1 lymphoid development controlling the production of the cytokine IFN- gamma. T-bet is widely expressed in hematopoietic cells including stem cells, NK cells, B cells, and T cells. T-bet is critical for the control of microbial pathogens and knockout animals show multiple physiologic and inflammatory features characteristic of asthma. T-bet expression is optimally observed after IL-12 stimulation and can be suppressed by addition of the Th2 cytokine IL-4 or neutralization of IL-12. The Poly6235 antibody recognizes human and mouse T-bet and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu, Mu |
| ALTnames: | anti-T box expressed in T cells antibody, anti-T box 21 antibody, anti-TBLYM antibody |
| ProteinTarget: | T-bet |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Szabo, S.J., et al. 2000. Cell 100:655.2. Szabo, S.J., et al. 2002. Science 295:338.3. Finotto, S., et al. 2002. Science 295:336.4. Mullen, A.C., et al. 2001. Science 292:1907. |
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