| CatalogCode: | NB100-78417 |
| ProductName: | Adiponectin Antibody |
| Product Description: | Rabbit Polyclonal anti-Adiponectin |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant (partial) |
| CrossReactivity: | Human. |
| Packaging: | 0.05 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Synthesized and secreted by adipocytes into plasma |
| Background: | Adiponectin is a 28 kD is a complement 1q family member that is involved in the control of fat metabolism and insulin sensitivity. Adiponectin forms multimers, under non-reducing, non-heat denaturing conditions with approximate molecular weights of gt300 kD, 167 kD, and 67 kD. Under reducing conditions with no heat, adiponectin is approximately 67 kD; under reducing conditions with heat, the adiponectin monomer has an apparent molecular weight of approximately 28 kD. Adiponectin can be modified by glycosylation and hydroxylation. Adiponectin is synthesized and secreted into plasma by adipocytes. Adiponectin has also been shown to act as a negative regulator of hematopoiesis and inflammation. In macrophages and endothelial cells adiponectin has been shown to downregulate TNF-induced adhesion molecules, and block NF- kappaB signaling though a cAMP-dependent mechanism. Decreased levels of adiponectin are associated with obesity insulin resistance and type 2 diabetes. IL-6 inhibits adiponectin production and secretion. Adiponectin has been shown to interact with collagen type I, III, and V. The Poly6215 antibody has been shown to be useful for Western blotting of human adiponectin. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Adipocyte-specific secretory protein antibody, anti-gelatin-binding factor 28 kD antibody |
| ProteinTarget: | Adiponectin |
| PackageSize: | 0.05 ml |
| GeneralRef: | 1. Yamauchi, T., et al., 2001. Nat. Med. 7:941. 2. Ouchi, N., et al., 2000. Circulation 102:1296. 3. Maeda, K., et al., 1996. Biochem. Biophys. Res. Commun. 221:286. |
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