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| Catalog Code: | NB100-78407 |
| Product Name: | Stathmin/Op18 Phosphospecific Antibody |
| Product Description: | Rabbit Polyclonal anti-Stathmin/Op18 [Ser16] |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Modified peptide |
| Cross Reactivity: | Human, reacts against Ser16-phosphorylated Stathmin/Op18. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Stathmin/Op18 is a 19 kD member of the Stathmin family. This protein is localized in the cytoplasm and becomes nuclear during the S/G2 phase of the cell cycle. Stathmin/Op18 acts as a microtubule destabilizer in mitotic spindle regulation and sequesters tubulin dimers into assembly-incompetent complexes. This protein participates as an intracellular relay integrating regulatory signals of the cellular environment and has been shown to be involved in megakaryocyte polyploidization. Stathmin/Op18 can be phosphorylated in response to heat; Ser62 phosphorylation reduces tubulin binding ability. This protein can also be modified by acetylation. Stathmin/Op18 has been shown to interact with tubulin, KIST, CaM kinase II and IV, Cdc2, MAPK, and Cdk1. The Poly6202 antibody recognizes human phosphorylated stathmin/Op18 (Ser16) and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Oncoprotein 18 antibody |
| Package Size: | 0.2 ml |
| Phosphorylated: | Ser16 |
| General References: | 1. Sobel, A., et al., 1989. J. Biol. Chem. 264:3765. 2. Labdon, J., et al., 1992. J. Biol. Chem. 267:3506. 3. Rubin, C., et al., 2003. Exp. Hematol. 31:389. 4. Honnappa, S., et al., 2003. J. Biol. Chem. 278:38926. |
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