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| Catalog Code: | NB100-78403 |
| Product Name: | Xbp-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-Xbp-1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Peptide-KLH (DTFANELFPQLISV) |
| Cross Reactivity: | Human, Rat, and weak reactive with Mouse; recognizes the 54 kD form. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. Immunohistochemistry-frozen/paraffin. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Xbp-1 (X-box binding protein 1) is a ubiquitously expressed 29 kD member of the CREB/ATF transcription factor family, and a mammalian homologue of the yeast transcription factor Hac1. Xbp-1 regulates MHC class II genes by binding to the X-box promoter motif and can also bind to the enhancer in T cell leukemia virus type I promoter to increase viral protein expression by binding the viral transactivator. This transcription factor is essential for hepatocyte differentiation and can be upregulated by ER stress, IL-6, and IL-4. The PAX5 transcription factor downregulates Xbp-1; downregulation has been shown to correlate with tumor progression in prostate cancer. The Poly6195 antibody recognizes the C-terminal region of human and rat Xbp-1 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2 |
| Application Summary: | immunohistochemistry, Western Blot |
| Species Summary: | Hu, Rt |
| Alternate Names: | anti-X-box binding protein 1 antibody, anti-XBP1 antibody |
| Package Size: | 0.2 ml |
| Preservative: | Sodium Azide |
| General References: | 1. Liou, H. C., et al., 1990. Science 247:1581. 2. Ponath, P. D., et al., 1993. J. Biol. Chem. 268:17074. 3. Takahashi, S., et al., 2002. Prostate 50:154. |
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