| CatalogCode: | NB100-78375 |
| ProductName: | SOCS6 Antibody |
| Product Description: | Rabbit Polyclonal anti-SOCS6 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant (partial) , N-terminal |
| CrossReactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Cytoplasm |
| Background: | The SOCS6 (suppressor of cytokine signaling-6) protein is a 59 kD cytoplasmic protein that contains a SOCS box and an SH2 domain. SOCS6 has been implicated as an inhibitor of IR signaling and has been shown to mediate cytokine-induced insulin resistance. SOCS6 is induced by erythropoietin and GM-CSF. The SOCS6 protein has been shown to interact with elongins B and C, and the insulin receptor. This protein forms a complex with IRS-4, IRS-2, and PI3K. The Poly6155 antibody recognizes the N-terminal region of human SOCS6 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Suppressor of cytokine signaling-6 antibody, anti-SOCS-6 antibody |
| ProteinTarget: | SOCS6 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Masuhara, M., et al., 1997. Biochem. Biophys. Res. Commun. 239:439. 2. Mooney RA, et al., 2001. J. Biol. Chem. 276:25889. 3. Krebs DL, et al., 2002. Mol Cell Biol. 22:4567. |
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