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| Catalog Code: | NB100-78336 |
| Product Name: | APC6 Antibody |
| Product Description: | Rabbit Polyclonal anti-APC6 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial), N-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use at 1:250-1:500 dilutions (5 ml total volume recommended for each mini-gel.) It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | APC6 (anaphase-promoting complex subunit 6) is a member of the E3 enzyme family. This protein contains TPR repeats and has a molecular weight of approximately 72 kD. The APC6 protein is located at the centrosome and mitotic spindle. This protein is required for core stability in the spindle checkpoint pathway. The APC6 protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC6 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6112 antibody recognizes the human APC6 protein and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Anaphase-promoting complex subunit 6 antibody, anti-Cell division cycle protein 16 (Cdc16) antibody, anti-Cut9 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Zachariae, W., et al., 1999. Genes Dev. 13:2039. 2. Tugendreich, S., et al., 1995 Cell. 81:261. 3. Golan, A., et al., 2002. J. Biol. Chem. 277:15552. 4. Lai, L., et al., 2003. Mol. Genet. Genomics. 270:156. |
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