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| Catalog Code: | NB100-78335 |
| Product Name: | APC5 Antibody |
| Product Description: | Rabbit Polyclonal anti-APC5 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial), N-terminal |
| Cross Reactivity: | Mouse, Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | APC5 (anaphase-promoting complex subunit 5) is a member of the E3 enzyme family. This protein has a molecular weight of approximately 79 kD. The APC5 protein is located in the nucleus during interphase and at the centrosome during metaphase/anaphase. This protein functions with other members of the APC complex as a multisubunit cell cycle ubiquitin ligase, and a regulator of sister chromatid separation by degrading securins. In addition, this protein functions in ubiquitin-dependent cyclin catabolism, metaphase/anaphase transition, and spindle elongation. The APC5 protein comprises one subunit of the anaphase promoting complex including APC1-8, and other probable complex proteins APC9-11, Cdc26, Mnd2, Swm1. The APC complex is inactivated by protein kinase A and is activated by CDC20 and Cdh1. The Poly6111 antibody has been shown to be useful for Western blotting of the human and mouse APC5 protein. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Mu, Hu |
| Alternate Names: | anti-Anaphase-promoting complex subunit 5 antibody, anti-Rmc1 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Jorgensen, P., et al., 1998. Mol. Cell. Biol. 18:468. 2. Zachariae, W., et al., 1999. Genes Dev. 13:2039. 3. Bentley, A., et al., 2002. J. Cell Sci. 115:949. 4. Hall, M., et al., 2003. J. Biol. Chem. 278:16698. |
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