| CatalogCode: | NB100-78329 |
| ProductName: | STAT 4 Antibody |
| Product Description: | Rabbit Polyclonal anti-STAT 4 |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant (partial) , N-terminal |
| CrossReactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Translocates to nucleus after phosphorylation. Expressed in NK cells, T lymphocytes, follicular lymp |
| Background: | STAT 4 is an 86 kD member of the STAT (signal transducer and activators of transcription) protein family that is phosphorylated in response to cytokine receptor-associated kinase activity. Phosphorylation of STAT 4 induces nuclear translocation to activate transcription. STAT 4 is expressed NK cells, T lymphocytes, follicular lymphomas, and placenta. STAT 4 forms both homo- and heterotrimers and is essential for IL-12 responses and the regulation of T helper cell differentiation. STAT 4 interacts directly with the IL-12 receptor and becomes phosphorylated in response to IL-12 and IFN- alpha signaling. The Poly6100 antibody recognizes the N-terminal region of human STAT4 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Signal transducer and activator of transcription 4 antibody |
| ProteinTarget: | STAT 4 |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Yamamoto, K., et al., 1994. Mol. Cell. Biol. 14:4342. 2. Bacon, C., et al., 1995. PNAS 92:7307. 3. Thierfelder, W., et al., 1996. Nature 382:171. 4. Mullen, A., et al., 2001. Science 292:1907. |
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