| request information: |
|
| Catalog Code: | NB100-78319 |
| Product Name: | p300 Antibody |
| Product Description: | Rabbit Polyclonal anti-p300 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial) , N-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | p300 (also known as E1A binding protein p300) is a 300 kD protein that is highly homologous to CREB-binding protein (CBP). p300 contains a histidine- and cysteine-rich domain and a bromodomain. This nuclear protein is ubiquitously expressed and acts as a histone acetylase regulating transcription via chromatin remodeling. p300 plays a role in cell proliferation, differentiation, and the hypoxia response. This protein is fused to MLL in leukemia and is mutated in a variety of epithelial cancers. p300 is stimulated by nerve growth factor or calcium-activated signaling in nerve cells and by TNF- alpha to increase p300-binding to transcription factors. p300 is modified by phosphorylation and can interact with CREB, c-Fos, c-Jun/v-Jun, Myb/v-Myb, TFIIB, MyoD, p53, HNF-4a, STAT3, STAT6, estrogen receptor alpha, and androgen receptor. This protein associates with PCAF, NR3C1, and NCOA6. The Poly6093 antibody recognizes the N-terminal region of human p300 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-E1A binding protein p300 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Yang, X., et al., 1996. Nature 382:319. 2. Arany, Z., et al., 1996. PNAS 93:12969. 3. Eckner, R., et al., 1994. Genes Dev. 8:869. 4. Ogryzko, V., et al., 1996. Cell 87:953. |
order or
more information: | company product webpage |
|
|