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| Catalog Code: | NB100-78303 |
| Product Name: | GATA 3 Antibody |
| Product Description: | Rabbit Polyclonal anti-GATA 3 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial), , N-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | GATA3 is a 45-50 kD transcription factor found in the nucleus of T cells, mast cells, and embryonic brain and kidney that contains a GATA-type zinc finger motif. This transcription factor recognizes and binds the GATA core nucleotide motif (A/T) GATA (A/G) and has been shown to regulate TH1 and TH2 cell differentiation by directly binding to the IL-5 and IL-13 promoters, remodeling chromatin structure to open the IL-4 locus, and repressing IL-12R beta-2 chain expression. GATA3 has been shown to be induced by IL-4 through Stat6 and can be upregulated by positive feedback. GATA-3 can be modified by acetylation and has been shown to interact with Smad3. The Poly6071 antibody has been shown to be useful for Western blotting of human GATA3. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Transcription factor GATA-3 antibody, anti-Enhancer binding protein Gata3 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Ho, I., et al., 1991. EMBO J. 10:1187. 2. Marine, J., et al., 1991. PNAS 88:7284. 3. Zhou, M., et al., 2003. Immunol. Res. 28:25. |
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