| CatalogCode: | | NB100-78297 |
| ProductName: | | eIF-2 alpha Antibody |
| Product Description: | | Rabbit Polyclonal anti-eIF-2 alpha |
| Clonality: | | Polyclonal |
| Immunogen: | | Recombinant (partial), C-terminal |
| CrossReactivity: | | Mouse, Human. |
| Packaging: | | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | | Cytoplasm, ubiquitously expressed |
| Background: | | eIF-2 alpha (also known as eukaryotic translation initiation factor 2, subunit 1 alpha) is a 35 kD member of the eukaryotic translation initiation factor 2 family. This cytoplasmic protein is ubiquitously expressed and can downregulate protein synthesis when phosphorylated by PKR kinase under stress conditions (hypoxia, viral infection, ER stress). Increased expression of eIF-2 alpha has been linked to progression of thyroid carcinoma.Signaling inhibited by p58 (IPK) and PKR phosphorylation. Can attenuate the unfolded protein response and inhibits translation. This protein has been shown to interact with eIF2B alpha, eIF2B delta, eIF2B beta subunit 2, p67, p68, and PKR. eIF-2 alpha is a target for cleavage by caspase 3, caspase 6, caspase 8, and caspase 10. The Poly6067 antibody recognizes both mouse and human eIF-2 alpha and has been shown to be useful for Western blotting. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | | 285 |
| AppSummary: | | WB |
| SpeciesSummary: | | Mu, Hu |
| ALTnames: | | anti-Eukaryotic translation initiation factor 2 antibody, anti-subunit 1 alpha antibody, anti-elf2 alpha antibody, anti-elf 2alpha antibody, anti-EIF2alpha antibody |
| ProteinTarget: | | eIF-2 alpha |
| PackageSize: | | 0.2 ml |
| GeneralRef: | | 1. Ernst, H., et al., 1987. J. Biol. Chem. 262:1206. 2. Van Huizen, R., et al., 2003. J. Biol. Chem. 278:15558 |
| more information: | | company product webpage |
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