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| Catalog Code: | NB100-78287 |
| Product Name: | SUMO I Antibody |
| Product Description: | Rabbit Polyclonal anti-SUMO I |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Full length recombinant human SUMO I |
| Cross Reactivity: | Human. |
| Packaging: | 0.05 ml protein A purified Rabbit antisera |
| Uses: | Each lot of this antibody has been quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | SUMO I (ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1, Ubiquitin-like protein SUMO-1) is a 17 kD member of the small ubiquitin-like modifier (SUMO) family, SMT3 subfamily. This nuclear protein has been shown to participate in sumoylation and regulate protein localization, protein stabilization, chromatin structure, DNA binding, and transcription. SUMO I is processed at a diglycine motif by SUMO hydrolase/isopeptidase to generate a free glycine residue that covalently attaches to protein substrates via a lysine residue on target proteins. The covalent attachment of SUMO I results in an approximate 17 kD modification in targeted proteins. SUMO I covalently attaches to a number of proteins including PML, SP100, p53, Mdm2, c-Jun, c-Myb, Sp3, Daxx, topoisomerase I and II, and I kappaB. The Poly6056 antibody recognizes human Sumo I and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Ubiquitin-like protein SMT3C antibody, anti-Ubiquitin-like protein UBL1 antibody, anti-Ubiquitin-like protein SUMO-1 antibody, anti-SUMO1 antibody, anti-SUMO 1 antibody |
| Package Size: | 0.05 ml |
| General References: | 1. Muller, S., et al., 2001. Nat. Rev. Mol. Cell. Biol. 2:202. 2. Verger, A., et al., 2003. EMBO Rep.. 4:137. 3. Desterro, J., et al., 1998. Mol. Cell. 2:233. 4. Kim, Y., et al., 1999. PNAS 96:12350. |
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