| CatalogCode: | NB100-78285 |
| ProductName: | c-Src Antibody |
| Product Description: | Rabbit Polyclonal anti-c-Src |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant (partial), N-terminal |
| CrossReactivity: | Mouse, Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | High levels in differentiated cells including neurons, platelets, macrophages, many tumors |
| Background: | c-Src (proto-oncogene tyrosine-protein kinase Src) is a 60 kD tyrosine protein kinase family containing both SH2 and SH3 domains. c-Src is expressed at high levels in differentiated cells including neurons, platelets, macrophages, many tumors. c-Src is a lipid-modified signaling molecule (myristolyated) involved in cell-cell interactions, cell migration, and proliferation through the phosphorylation of many substrates including beta-catenin, paxillin, and vinculin. Phosphorylation of c-Src on Tyr-526 by Csk (c-Src kinase) represses activity; c-Src is activated by phospholipase D, insulin-like growth factor receptor, EGF-receptor, fibroblast growth factor receptor, and prolactin receptor binding. c-Src has been shown to be phosphorylated on multiple sites and to interact with polyoma virus middle T antigen, PYK2, HSP72, and caveolin. The Poly6054 antibody recognizes the N-terminal region of human and mouse c-Src and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Mu, Hu |
| ALTnames: | anti-Proto-oncogene tyrosine-protein kinase Src antibody, anti-p60-Src antibody, anti-pp60c-src antibody |
| ProteinTarget: | c-Src |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Cooper, J., et al., 1986. Science 231:1431. 2. Ahn, B., et al., 2003. Mol. Cell. Biol. 23:3103. 3. Kilkenny, D., et al., 2003. J. Biol. Chem. 278:17448. |
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