| CatalogCode: | NB100-78282 |
| ProductName: | PI3K p110 delta Antibody |
| Product Description: | Rabbit Polyclonal anti-PI3K p110 delta |
| Clonality: | Polyclonal |
| Immunogen: | Recombinant (partial) Amino acid residues 450-550 |
| CrossReactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Autophosphorylates, does not phosphorylate p85 like PI3K p110 #948. Exhibits broad phosphoinositide |
| Background: | PI3K p110 delta (phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit delta isoform) is a member of the PI3/PI4 kinase family containing a B-Zip domain. This 110 kD protein autophosphorylates, but does not phosphorylate p85 like PI3K p110 delta. PI3K p110 delta exhibits a broad phosphoinositide lipid substrate specificity and is required for directional movement in neutrophils, and is involved in B and T cell receptor complex signaling. This isoform interacts with SH2/SH3 domain-containing p85 adaptor proteins and GTP-bound Ras and consists of catalytic p110 and regulatory p85 subunits and is activated by IL-3, IL-4 and SCF. PI3K is modified by phosphorylation. The Poly6049 antibody recognizes human PI3K p100 delta and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host_Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | 285 |
| AppSummary: | WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Phosphatidylinositol-4,5-biphosphate 3-kinase catalytic subunit delta isoform antibody, anti-PI3K p110&delta antibody |
| ProteinTarget: | PI3K p110 delta |
| PackageSize: | 0.2 ml |
| GeneralRef: | 1. Vanhaesebroeck, B., et al., 1997. PNAS 94:4330. 2. Jou, S., et al., 2002. Mol. Cell. Biol. 22:8580. 3. Sadhu, C., et al., 2003. J. Immunol. 170:2647. 4. Okkenhaug, K., et al., 2002. Science 297:1031. |
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