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| Catalog Code: | NB100-78276 |
| Product Name: | ILK-1 Antibody |
| Product Description: | Rabbit Polyclonal anti-ILK-1 |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial) , N-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | ILK-1 (also known as integrin linked kinase 1) is a 59 kD is a serine/threonine protein kinase, containing ankyrin repeats and PH-like domain. This protein is localized in the cytoplasm and is highly expressed in skeletal muscle, pancreas and kidney. ILK-1 is a receptor proximal protein kinase regulating integrin-mediated signal transduction. This focal adhesion protein is part of the PINCH-ILK complex involved in maintaining cellular architecture, adhesion to integrin substrates, and anchorage-dependent growth. ILK-1 phosphorylates beta1 and beta3 integrin subunits, AKT1, and GSK3 beta. ILK-1 is stimulated by cell-fibronectin interactions and insulin signaling. ILK-1 is phosphorylated on serine residues. ILK-1interacts with the cytoplasmic domain of beta-1 integrin subunit, PINCH, and the parvins. The Poly6043 antibody recognizes the N-terminal region of human ILK-1 and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Integrin linked kinase 1 antibody, anti-Integrin-linked kinase antibody, anti-p59 ILK antibody, anti-ILK 1 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. Hannigan, G., et al., 1996. Nature 379:91. 2. Delcommenne, M, et al., 1998. PNAS 95:11211. 3. Dedhar, S. 2000. Curr. Opin. Cell Biol. 12:250. |
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