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| Catalog Code: | NB100-78267 |
| Product Name: | Prohibitin Antibody |
| Product Description: | Rabbit Polyclonal anti-Prohibitin |
| Clonality: | Polyclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant (partial), C-terminal |
| Cross Reactivity: | Human. |
| Packaging: | 0.2 ml protein A purified Rabbit antisera |
| Uses: | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Prohibitin is a 30 kD member of the band 7 family containing a SPFH domain. Prohibitin is localized the nucleus and mitochondrial inner cell membrane. This protein functions as a negative regulator of cell proliferation associated with senescence and cell death and a transcriptional repressor via recruitment of Brg-1, Brm or N-CoR, or HDAC1. Prohibitin can also function as a membrane-bound chaperone for the assembly of the mitochondrial respiratory chain complex. Prohibitin is induced by metabolic stress caused by imbalance in synthesis of mitochondrial-, nuclear-encoded mitochondrial proteins. Prohibitin can be modified by phosphorylation and ubiquitination. This protein has been shown to interact with Rb, Brg-1, Brm, N-CoR, HDAC1, and PHB2. The Poly6031 antibody recognizes the C-terminal region of human prohibitin and has been shown to be useful for Western blotting. |
| Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | protein A purified |
| Isotype: | IgG |
| Host Name: | Rabbit |
| Buffer: | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| Application Summary: | Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-PHB antibody, anti-PHB1 antibody |
| Package Size: | 0.2 ml |
| General References: | 1. White, J., et al., 1991. Genomics 11:228. 2. Nijtmans, L., et al., 2002. Cell Mol. Life Sci. 59:143. 3. Wang, S., et al., 2002. Oncogene 21:8388. 4. Thompson, W., et al., 2003. Biol. Reprod. 69:254. |
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