| CatalogCode: | | NB100-78253 |
| ProductName: | | Cdk7 Antibody |
| Product Description: | | Rabbit Polyclonal anti-Cdk7 |
| Clonality: | | Polyclonal |
| Immunogen: | | Recombinant (partial), N-terminal |
| CrossReactivity: | | Human. |
| Packaging: | | 0.2 ml Immunogen affinity purified Rabbit antisera |
| Uses: | | Each lot of this antibody is quality control tested by Western blotting. Western blotting, suggested working dilution(s): Use 10 mul per 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | | Nuclear |
| Background: | | CAK (also known as CDK-activating kinase, CDK7 and cell division protein kinase 7) is a 40 kD nuclear protein that is a member of the serine/threonine family of protein kinases, CDC2/CDKX subfamily. CAK activates cyclin-associated kinases CDC2/CDK1, CDK2, CDK4, CDK6 by threonine phosphorylation and controls cell cycle progression, DNA repair, and RNA polymerase II transcription. CAK is activated by phosphorylation at Thr170 and is inactivated by phosphorylation at Ser164. CAK has been reported to interact with cyclin H and MAT1 to form the CAK complex, the CAK complex then interacts with core-TFIIH to form the TFIIH basal transcription factor. The Poly6015 antibody is useful for Western blotting and immunoprecipitation of the human CAK protein. |
| Storage: | | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG |
| Host_Name: | | Rabbit |
| Buffer: | | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and |
| ListPrice: | | 285 |
| AppSummary: | | IP, WB |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-Cyclin-dependent kinase 7 antibody, anti-CDK-activating kinase (CAK) antibody |
| ProteinTarget: | | Cdk7 |
| PackageSize: | | 0.2 ml |
| GeneralRef: | | 1. Tassan, J., et al., 1994. J. Cell. Biol. 127:467. 2. Tirode, F., et al., 1999. Mol. Cell. 3:87. 3. Akoulitchev, S., et al., 1998. Genes Dev. 12:3541. 4. Chen, J., et al., 2003. Nature. 424:228. |
| more information: | | company product webpage |
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