| CatalogCode: | NB100-78153 |
| ProductName: | GM-CSF Antibody |
| Product Description: | Rat Monoclonal anti-GM-CSF (BVD2-21C11) |
| Clone: | BVD2-21C11 |
| Clonality: | Monoclonal |
| Immunogen: | E. coli - expressed, recombinant human GM-CSF |
| CrossReactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Rhesus. |
| Packaging: | 0.5 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. The purified BVD2-21C11 has been tested by blocking fluorochrome conjugated BVD2-21C11 for intracellular cytokine staining. In order to obtain complete blocking results, a saturated amount of purified antibody ( le 5.0 ug/million cells) should be used for incubation with target cells, prior to staining with fluorochrome conjugated antibody. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Granulocyte/macrophage/erythroid/megakaryocytic progenitors, myeloblasts, monoblasts |
| Background: | Granulocyte/macrophage - colony stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T cells, B cells, mast cells, macrophages, fibroblasts and endothelial cells. In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte and eosinophil progenitors. The BVD2-21C11 antibody reacts with human granulocyte/macrophage-colony stimulating factor (GM-CSF). The BVD2-21C11 antibody can neutralize the bioactivity of natural or recombinant GM-CSF. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host_Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 295 |
| AppSummary: | ICC, FACS, IHC, IP, WB |
| SpeciesSummary: | Hu |
| ALTnames: | anti-Granulocyte-Colony Stimulating Factor antibody, anti-CSF-beta antibody, anti-Pluripoietin antibody, anti-Granulocytic neutrophil colony stimulating activity (G-CSA) antibody, anti-Macrophage-granulocyte inducer-2 (MGI-2) antibody |
| ProteinTarget: | GM-CSF |
| PackageSize: | 0.5 mg |
| GeneralRef: | 1. Fitzgerald, K., et al., Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Demetri, G., et al., 1991. Blood 78:2791. 3. Fan, D., et al., 1991. In vivo 5:571. |
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