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| Catalog Code: | NB100-78147 |
| Product Name: | IL-12 Antibody |
| Product Description: | Mouse Monoclonal anti-IL-12 (C8.3) |
| Clone: | C8.3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | COS-expressed p40 subunit of human IL-12 |
| Cross Reactivity: | Human, IL-12/IL-23 p40 - specific (not reactive with IL-12 p70 and IL23 p19/p40). |
| Packaging: | 0.5 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by ELISA assay. For ELISA capture applications, a concentration range of 2-6 mug/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application. To obtain a linear standard curve, serial dilutions of IL-12 (p40) recombinant protein ranging from 4000 to 30 pg/ml are recommended for each ELISA plate. |
| Background: | The C8.3 antibody reacts with human interleukin-12 and interleukin-23 (IL-12/IL-23) p40 monomer or homodimer. This antibody does not react with either the p35 subunit of IL-12 or the p19 subunit of IL-23, or the p40 protein when it is heterodimerized with p35 (the IL-12 p70) or p19 (IL-23 p60). The C8.3 antibody cannot neutralize the antagonistic activity of IL-12 p40. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | ELISA |
| Species Summary: | Hu |
| Alternate Names: | anti-Interleukin-12 p40 antibody, anti-Interleukin-23 p40 antibody, anti-Cytotoxic lymphocyte maturation factor (CLMF) antibody, anti-Natural killer cell stimulatory factor (NKSF) antibody, anti-CTL maturation factor (TcMF) antibody, anti-T-cell stimulating factor (TSF) antibody |
| Package Size: | 0.5 mg |
| Notes Main: | This antibody can be used in a sandwich ELISA (coating - conjugate) with the following clone pair: C8.3 - C8.6 For Sandwich ELISA pair this antibody with: NB100-78225 |
| General References: | 1. Fitzgerald, K., et al., Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Quesniaux, V. 1992. Research Immunol. 143:385. 3. Trinchieri, G., et al., 1992 Prog. Growth Factor Res. 4:355. |
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