| CatalogCode: | | NB100-78110 |
| ProductName: | | CD49e Antibody |
| Product Description: | | Mouse Monoclonal anti-CD49e (NKI-SAM-1), conjugated to FITC |
| Clone: | | NKI-SAM-1 |
| Clonality: | | Monoclonal |
| Immunogen: | | U937 cells |
| CrossReactivity: | | Human. |
| Packaging: | | 100 tests Immunogen affinity purified Mouse antisera |
| Uses: | | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microliter per million cells or 20 microliter per 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | | Thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, some myeloid leukemia c |
| Background: | | CD49e is a type I integral membrane glycoprotein, known as alpha5 integrin, VLA-5 alpha chain. It forms noncovalent heterodimer with integrin beta1 (CD29). CD49e contains two disulfide-linked subunits of 135 kDa and 24 kDa, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronection and neural adhesion molecule L1. It mediates monocytes migration, involves in the regulation of cells survival and apoptosis, and co-stimulates T cell activation. |
| Storage: | | Store at 4C. Do not freeze. |
| Purity: | | Immunogen affinity purified |
| Isotype: | | IgG2b, kappa |
| Host_Name: | | Mouse |
| Buffer: | | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| ListPrice: | | 285 |
| AppSummary: | | FACS |
| SpeciesSummary: | | Hu |
| ALTnames: | | anti-alpha 5 integrin antibody, anti-VLA-5 alpha chain antibody, anti-Integrin alpha 5 integrin antibody, anti-integrin a5 antibody |
| ProteinTarget: | | CD49e |
| PackageSize: | | 100 tests |
| Conjugate: | | FITC |
| GeneralRef: | | 1.Tran Van Nhieu, GT. and RR. Isberg. 1991. J. Biol. Chem. 266:24367.2. Isaji, T., et al. 2006.J. Biol. Chem. 281:33258. |
| more information: | | company product webpage |
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