| CatalogCode: | NB100-78109 |
| ProductName: | CD49e Antibody |
| Product Description: | Mouse Monoclonal anti-CD49e (NKI-SAM-1), conjugated to Biotin |
| Clone: | NKI-SAM-1 |
| Clonality: | Monoclonal |
| Immunogen: | U937 cells |
| CrossReactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, some myeloid leukemia c |
| Background: | CD49e is a type I integral membrane glycoprotein, known as alpha5 integrin, VLA-5 alpha chain. It forms noncovalent heterodimer with integrin beta1 (CD29). CD49e contains two disulfide-linked subunits of 135 kDa and 24 kDa, and is mainly expressed on thymocytes, activated lymphocytes, endothelial cells, osteoblasts, melanoma, and some myeloid leukemia cells. CD49e/CD29 complex binds to fibronection and neural adhesion molecule L1. It mediates monocytes migration, involves in the regulation of cells survival and apoptosis, and co-stimulates T cell activation. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host_Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 285 |
| AppSummary: | FACS, IHC |
| SpeciesSummary: | Hu |
| ALTnames: | anti-alpha 5 integrin antibody, anti-VLA-5 alpha chain antibody, anti-Integrin alpha 5 integrin antibody, anti-integrin a5 antibody |
| ProteinTarget: | CD49e |
| PackageSize: | 0.1 mg |
| Conjugate: | Biotin |
| GeneralRef: | 1.Tran Van Nhieu, GT. and RR. Isberg. 1991. J. Biol. Chem. 266:24367.2. Isaji, T., et al. 2006.J. Biol. Chem. 281:33258. |
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