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| Catalog Code: | NB100-78089 |
| Product Name: | CD74 Antibody |
| Product Description: | Mouse Monoclonal anti-CD74 (LN2) |
| Clone: | LN2 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | SU-DHL-4 cells |
| Cross Reactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Baboon. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume or 100 microliter whole blood. Immunohistochemistry-frozen/paraffin. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD74 is a type II transmembrane glycoprotein, also known as MHC Class II associated invariant chain, invariant chain, Ii, MHC class II chaperone, or MIF receptor. CD74 exists in 4 isoforms with the molecular sizes 33, 35, 41, and 43 kDa depending on genetic splicing. CD74 is primarily expressed on antigen presenting cells, including B cells, monocytes/macrophages, dendritic cells, and Langerhans cells. It is also expressed by activated T cells, activated endothelial and epithelial cells as well as the carcinomas of lung, renal, gastric and thymic origin. The primary function of CD74 is for intracellular sorting of the MHC class II molecules, regulation of loading exogenous peptides onto MHC class II. It is also involved in the modulation of B cell differentiation and positive selection of CD4+ T cells. It has been reported that CD74 binds MIF (macrophage migration inhibitory factory) and signaling through CD44 to regulate innate and adaptive immunity, and that the H. pylori infection is through urease B binding CD74 on gastric epithelial cells and inducing cell activation. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry, immunoprecipitation |
| Species Summary: | Hu, Bb |
| Alternate Names: | anti-MHC Class II associated invariant chain antibody, anti-invariant chain antibody, anti-Ii antibody, anti-MHC class II chaperone antibody, anti-MIF receptor antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Moldenhauer, G., et al. 1999. Immunology 96:473.2. Shi, X., et al. 2006. Immunity 25:595.3. Beswick, EJ., et al. 2006. Infect. Immun. 74:1148. |
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