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| Catalog Code: | NB100-78050 |
| Product Name: | LT- betaR Antibody |
| Product Description: | Mouse Monoclonal anti-LT- betaR (31G4D8) |
| Clone: | 31G4D8 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Human LT- betaR Fc protein |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 2.0 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | LT- betaR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LT- betaR is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LT- betaR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LT- betaR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LT- betaR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LT- betaR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs. The 31G4D8 antibody has been shown to be useful for flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT- betaR capable of inducing apoptosis (with IFN- gamma treatment). |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis, immunoprecipitation, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Lymphotoxin beta receptor antibody, anti-Tumor necrosis factor receptor superfamily member 3 LT-bR antibody, anti-LT-beta receptor antibody, anti-TNFR3 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Crowe, P.D., et al., 1994 Science 264:707. 2. Wu, M.-Y., et al., 1999. J. Biol. Chem. 274:11868.3. Rooney, I.A., et al., 2000. J. Biol. Chem. 275:14307. |
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