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| Catalog Code: | NB100-78019 |
| Product Name: | CD256 Antibody |
| Product Description: | Mouse Monoclonal anti-CD256 (T3-6) |
| Clone: | T3-6 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | recombinant human APRIL protein |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | The T3-6 antibody recognizes human APRIL (CD256) also known as A proliferation-inducing ligand, TNF- and APOL-related leukocyte expressed ligand 2 (TALL-2), TNF-related death ligand 1, and TNFSF13. APRIL is a member of the TNF superfamily, synthesized as a type II transmembrane protein, but cleaved by furin intracellularly to become secreted factor.. Several isoforms of APRIL can be produced by alternative splicing. APRIL, like other members of the TNF ligand superfamily, forms homodimers. The reported molecular weight of an APRIL monomer is approximately 27 kD. APRIL is highly expressed in transformed cell lines, cancers of colon, thyroid, and lymphoid tissues. Monocytes and macrophages also express APRIL; expression of APRIL is down-regulated following PMA/ionomycin treatment. APRIL has been implicated in B cell development and IgA class switching, T cell survival, and the stimulation of tumor cell growth. T3-6 antibody has been shown to be useful for flow cytometry and ELISA. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | ELISA, flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-APRIL antibody, anti-TALL-2 antibody, anti-TALL2 antibody, anti-A proliferation-inducing ligand antibody, anti-TNF and APOL-related leukocyte expressed ligand 2 (TALL-2) antibody, anti-TNF-related death ligand 1 antibody, anti-TNFSF13 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Stein, J.V., et al. 2002. J. Exp. Med. 109:1587.2. Yu, G., et al. 2000. Nat. Immunol. 1:252.3. Castigli, E., et al. 2004 |
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