| CatalogCode: | NB100-77989 |
| ProductName: | CD226 Antibody |
| Product Description: | Mouse Monoclonal anti-CD226 (DX11), conjugated to FITC |
| Clone: | DX11 |
| Clonality: | Monoclonal |
| Immunogen: | Human cytotoxic T lymphocytes |
| CrossReactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus. |
| Packaging: | 100 tests Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microliter per million cells or 20 microliter per 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Majority of T cells, NK cells, monocytes, platelets, subset of B cells |
| Background: | CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host_Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| ListPrice: | 285 |
| AppSummary: | FACS |
| SpeciesSummary: | Hu, Bb, Mk |
| ALTnames: | anti-DNAM-1 (DNAX Accessory Molecule-1) antibody, anti-PTA1 antibody, anti-TLiSA1 antibody |
| ProteinTarget: | CD226 |
| PackageSize: | 100 tests |
| Conjugate: | FITC |
| GeneralRef: | 1. Shibuya, A., et al., 1996. Immunity 4(6): 573.2. Chen, L., et al., 2003. Life Sci. 73(18): 2373.3. Bottino, C., et al., 2003. J. Exp. Med. 198(4): 557. |
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