| CatalogCode: | NB100-77988 |
| ProductName: | CD226 Antibody |
| Product Description: | Mouse Monoclonal anti-CD226 (DX11) |
| Clone: | DX11 |
| Clonality: | Monoclonal |
| Immunogen: | Human cytotoxic T lymphocytes |
| CrossReactivity: | Human, Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per million cells or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Control: | Majority of T cells, NK cells, monocytes, platelets, subset of B cells |
| Background: | CD226 is a 65kD type I transmembrane glycoprotein, known as DNAM-1 (DNAX accessory molecule-1), PTA1(platelet and T cell activation antigen 1), or TLiSA1 (T lineage-specific activation antigen 1 antigen). It belongs to immunoglobulin superfamily containing 2 Ig-like domains, is expressed on majority of T lymphocytes, NK cells, monocytes, platelets, and a subset of B cells, activated endothelial cells. DNAM-1 is also expressed on CD8+ (but not CD8-) dendritic cells in mouse model. CD226 is an adhesion molecule involved in CTL and NK cell-mediated cytotoxicity. It has been identified that CD155 (poliovirus receptor, PVR) and CD112 (nectin-2, PRR-2) are CD226 ligands. DX11 antibody is able to inhibit CTL and NK cell-mediated cytotoxicity, and to block T cell cytokine production. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host_Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| ListPrice: | 180 |
| AppSummary: | FACS, IP |
| SpeciesSummary: | Hu, Bb, Mk |
| ALTnames: | anti-DNAM-1 (DNAX Accessory Molecule-1) antibody, anti-PTA1 antibody, anti-TLiSA1 antibody |
| ProteinTarget: | CD226 |
| PackageSize: | 0.1 mg |
| GeneralRef: | 1. Shibuya, A., et al., 1996. Immunity 4(6): 573.2. Chen, L., et al., 2003. Life Sci. 73(18): 2373.3. Bottino, C., et al., 2003. J. Exp. Med. 198(4): 557. |
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