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| Catalog Code: | NB100-77979 |
| Product Name: | CD72 Antibody |
| Product Description: | Mouse Monoclonal anti-CD72 (3F3), conjugated to FITC |
| Clone: | 3F3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | human lymphocytes |
| Cross Reactivity: | Human. |
| Packaging: | 100 tests Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microliter per million cells or 20 microliter per 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD72 is a 39-43 kD type II membrane glycoprotein. It is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-Lyb-2 antibody, anti-Ly-19.2 antibody, anti-Ly-32.2 antibody, anti-Lyb2 antibody, anti-Ly19.2 antibody, anti-Ly32.2 antibody |
| Package Size: | 100 tests |
| Conjugate: | FITC |
| General References: | 1. Knapp, W., et al., Eds. 1989. Leucocyte Typing IV. Oxford University Press. New York.2. Schwarting, T., et al., 1992. Am. J. Hematol. 41: 151.3. Wu, HJ., and S. Bondata. 2002. Immunol. Res. 25: 155. |
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