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| Catalog Code: | NB100-77968 |
| Product Name: | CD98 Antibody |
| Product Description: | Mouse Monoclonal anti-CD98 (MEM-108) |
| Clone: | MEM-108 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Burkitt's lymphoma cell line Raji |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD98 is a 125 kD disulfide-linked heterodimer protein also known as 4F2 and FRP-1. It is broadly expressed on activated and transformed cells (hematopoietic and non-hematopoietic), and at low levels on quiescent cells. CD98 has been characterized as a potential amino acid transporter (neutral and dibasic amino acids) that is involved in lymphocyte activation and integrin signaling. CD98 is composed of a light chain (45 kD) and a heavy chain (80 kD). Studies with knock-out mice indicate that the CD98 heavy chain is involved in integrin-dependent cell spreading and protection against anchorage deprivation-induced apoptosis. The MEM-108 antibody is useful for flow cytometry and immunoprecipitation. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis, immunoprecipitation |
| Species Summary: | Hu |
| Alternate Names: | anti-4F2 antibody, anti-FRP-1 antibody, anti-RL-388 antibody, anti-FRP1 antibody, anti-RL388 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Leukocyte Typing VI. Kishimoto, T., et al., (Eds.) Garland Publishing Inc. (1997)2. Bron, C., et al., 1986. J. Immunol. 137:397.3. Lumadue, J.A., et al., 1987. Proc. Natl. Acad. Sci. 84:9204. |
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