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| Catalog Code: | NB100-77955 |
| Product Name: | TLR3 Antibody |
| Product Description: | Mouse Monoclonal anti-TLR3 (TLR-104) |
| Clone: | TLR-104 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Recombinant human Toll-like receptor 3 protein |
| Cross Reactivity: | Human. |
| Packaging: | 0.25 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume. For Western blotting, suggested working dilution(s)is 10 microgram antibody in 5 ml antibody dilution buffer for each mini-gel. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | Toll-like receptor 3 (TLR3) is a 104 kD protein also known as CD283. It is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. TLR3 is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens. The ligands recognized by TLR3 are polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. TLR3 ligands induce NF- kappaB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. This antibody is useful for flow cytometry and Western blotting. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | Immunocytochemistry, flow cytometry / FACS analysis, Western Blot |
| Species Summary: | Hu |
| Alternate Names: | anti-Toll like receptor 3 antibody, anti-TLR-3 antibody, anti-TLR3 antibody, anti-CD283 antibody |
| Package Size: | 0.25 mg |
| General References: | 1. Alexopoulou, L., et al., 2001. Nature 413:732.2. Doyle, S.E., et al., 2002. Immunity 17:251.3. Meylan, E., et al., 200 |
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