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| Catalog Code: | NB100-77938 |
| Product Name: | CD49f Antibody |
| Product Description: | Rat Monoclonal anti-CD49f (GoH3), conjugated to FITC |
| Clone: | GoH3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Mouse mammary tumor cells |
| Cross Reactivity: | Human, Mouse, Expected Cross-Reactivity based on immunogen sequence: Baboon, Cynomolgus, Rhesus, Horse (Equine), Cattle (Bovine, Cow), Sheep (Ovine), Swine (Pig, Porcine), Dog (Canine), Cat (Feline), Rabbit (Lapine). |
| Packaging: | 100 tests Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is 20 microliter per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD49f is a 120 kD integrin family member, also known as VLA-6 alpha chain and alpha6 integrin subunit. CD49f associates with either integrin beta1 (CD29) or integrin beta4 (CD104) to form receptors (VLA-6 or alpha6 beta4 complex) for laminin and kalinin. CD49f is expressed on platelets, monocytes, T cells, placental trophoblasts, epithelial and endothelial cells. CD49f is involved in adhesion and can act as a co-stimulatory molecule for T cell activation and proliferation. The GoH3 antibody has been reported to block laminin binding in vitro and to block integrin alpha6 function in vivo. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA (origin USA). |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu, Mu, Bb, Mk, Eq, , Bv, , Sh, , Po, , Ca, , Fe, , Rb |
| Alternate Names: | anti-VLA-6 alpha antibody, anti-alpha 6 integrin antibody, anti-integrin alpha 6 antibody, anti-integrin a6 antibody |
| Package Size: | 100 tests |
| Conjugate: | FITC |
| General References: | 1. Sonnenberg A., et al. 1990. J. Cell. Biol. 110:2145.2. Sonnenberg, A., et al. 1990. J. Cell. Sci. 96:207.3. Aumailly, M.R., et al. 1990. Exp. Cell Res. 188:55. |
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