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| Catalog Code: | NB100-77937 |
| Product Name: | CD49f Antibody |
| Product Description: | Rat Monoclonal anti-CD49f (GoH3), conjugated to Biotin |
| Clone: | GoH3 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Mouse mammary tumor cells |
| Cross Reactivity: | Human, Mouse, Expected Cross-Reactivity based on immunogen sequence: Baboon, Cynomolgus, Rhesus, Horse (Equine), Cattle (Bovine, Cow), Sheep (Ovine), Swine (Pig, Porcine), Dog (Canine), Cat (Feline), Rabbit (Lapine). |
| Packaging: | 0.1 mg Immunogen affinity purified Rat antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CD49f is a 120 kD integrin family member, also known as VLA-6 alpha chain and alpha6 integrin subunit. CD49f associates with either integrin beta1 (CD29) or integrin beta4 (CD104) to form receptors (VLA-6 or alpha6 beta4 complex) for laminin and kalinin. CD49f is expressed on platelets, monocytes, T cells, placental trophoblasts, epithelial and endothelial cells. CD49f is involved in adhesion and can act as a co-stimulatory molecule for T cell activation and proliferation. The GoH3 antibody has been reported to block laminin binding in vitro and to block integrin alpha6 function in vivo. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2a, kappa |
| Host Name: | Rat |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu, Mu, Bb, Mk, Eq, , Bv, , Sh, , Po, , Ca, , Fe, , Rb |
| Alternate Names: | anti-VLA-6 alpha antibody, anti-alpha 6 integrin antibody, anti-integrin alpha 6 antibody, anti-integrin a6 antibody |
| Package Size: | 0.1 mg |
| Conjugate: | Biotin |
| General References: | 1. Sonnenberg A., et al. 1990. J. Cell. Biol. 110:2145.2. Sonnenberg, A., et al. 1990. J. Cell. Sci. 96:207.3. Aumailly, M.R., et al. 1990. Exp. Cell Res. 188:55. |
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