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| Catalog Code: | NB100-77934 |
| Product Name: | CD278 Antibody |
| Product Description: | Hamster Monoclonal anti-CD278 (C398.4A) |
| Clone: | C398.4A |
| Clonality: | Monoclonal |
| ListPrice: | 315 |
| Immunogen: | Mouse T cell clone D10.G4.1 |
| Cross Reactivity: | Human, Mouse, Rat. |
| Packaging: | 0.5 mg Immunogen affinity purified Hamster antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume. Immunohistochemistry-frozen sections. It is recommended that reagents be titrated for optimal performance in the particular application. |
| Background: | The C398.4A antibody reacts with the human, mouse and rat 47-57 kD ICOS protein, also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. The C398.4A antibody is useful for flow cytometric analysis and is able to costimulate T cell activation and proliferation. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG |
| Host Name: | Hamster |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis , immunoprecipitation , Immunohistochemistry-Frozen |
| Species Summary: | Hu, Mu, Rt |
| Alternate Names: | anti-Inducible COStimulatory molecule antibody, anti-H4 antibody, anti-CD278 antibody |
| Package Size: | 0.5 mg |
| General References: | 1. Redoglia, V., et al. 1996. Eur. J. Immunol. 26:2781.2. Hutloff, A., et al. 1999. Nature 397:263.3. Buonfiglio, D., et al. 2000. Eur. J. Immunol. 30:3463. |
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