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| Catalog Code: | NB100-77897 |
| Product Name: | CCR3 Antibody |
| Product Description: | Mouse Monoclonal anti-CCR3 (5E8) |
| Clone: | 5E8 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | CC-chemokine receptor 3 (CCR3), also known as CC CKR3, MIP1-alpha receptor like-2, eotaxin receptor, and CD193, is a member of G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and -2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG2b, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-CC CKR3 antiobyd, anti-MIP1-alpha receptor like-2 antibody, anti-eotaxin receptor antiobyd, anti-CD193 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Gerard, W., et al., 1996. J. Exp. Med. 183:2437. 2. Uguccioni, C., et al., 1997. J. Clin. Invest. 100:1137. 3. Sallusto, F., et al., 1997. Science 277:2005. |
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