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| Catalog Code: | NB100-77874 |
| Product Name: | DcR2 Antibody |
| Product Description: | Mouse Monoclonal anti-DcR2 (DJR4-2) |
| Clone: | DJR4-2 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Extracellular domain of DcR2-human IgG1 Fc fusion protein |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | DcR2 (decoy receptor 2), also known as TRAIL-R4, TRUNDD, and CD264, is 386 amino acids in length and a member of the TNF receptor family. Although this receptor binds to the cytotoxic ligand TRAIL, it contains a truncated death domain and functions as an inhibitory receptor. When overexpressed, the DcR2 receptor can protect cells against TRAIL-mediated cytotoxicity. The DcR2 receptor is expressed in a variety of normal human tissues, but is absent in most tumors. Ultraviolet radiation has been shown to upregulate DcR2 expression on human keratinocytes. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-TRAIL-R4 antibody, anti-TRAILR4 antibody, anti-TRUNDD antibody, anti-CD264 antibody, anti-TNFRSF10D antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Degli-Esposti, M., et al., 1997. Immunity 7:813. 2. Marsters, S., et al., 1997. Curr. Biol. 7:1003. 3. Maeda, T., et al., 2001. J. Cutan. Med. Surg. 5:294. |
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