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| Catalog Code: | NB100-77867 |
| Product Name: | TWEAK Antibody |
| Product Description: | Mouse Monoclonal anti-TWEAK (CARL-1) |
| Clone: | CARL-1 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | hTWEAK/2PK-3 transfectant cells |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per one million cells in 100 microliter volume or 100 microliter of whole blood. Immunohistochemistry. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | TNF-like weak inducer of apoptosis (TWEAK) is a type II transmembrane TNF superfamily member with strong homology to TNF in its extracellular portion, though less potent in inducing apoptosis. It has been clustered as CD255. TWEAK transcript is expressed broadly in many adult and fetal tissues; however, the staining of human peripheral blood mononuclear cells with TWEAK-specific antibodies shows a more restricted pattern. TWEAK is expressed as membrane-bound and secreted forms. Interaction of TWEAK with its receptors (DR3, Fn14) promotes secretion of IL-8, activation of NF- kappaB, proliferation of endothelial cells, and apoptosis in a number of human cell lines. |
| Storage: | Store at 4C. Do not freeze. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG3, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis, immunohistochemistry |
| Species Summary: | Hu |
| Alternate Names: | anti-TNF-like weak inducer of apoptosis antibody, anti-Apo-3 ligand (Apo3L) antibody, anti-Death receptor 3-L (DR3-L) antibody, anti-TNFSF 12 antibody, anti-CD255 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. Fitzgerald, K., et al., Eds. 2001. The Cytokine FactsBook. Academic Press, San Diego. 2. Chicheportiche, Y., et al., 1997. J. Biol. Chem. 272:32401. 3. Kaplan, M., et al., 2000. J. Immunol. 164:2897. |
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