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| Catalog Code: | NB100-77852 |
| Product Name: | DR5 Antibody |
| Product Description: | Mouse Monoclonal anti-DR5 (DJR2-4) |
| Clone: | DJR2-4 |
| Clonality: | Monoclonal |
| ListPrice: | 295 |
| Immunogen: | Extracellular domain of DR5-human IgG1 Fc fusion protein |
| Cross Reactivity: | Human. |
| Packaging: | 0.1 mg Immunogen affinity purified Mouse antisera |
| Uses: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 0.5 microgram per million cells in 100 microliter volume or 100 microliter of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
| Background: | DR5 is 55 kD member 10B of the TNF receptor superfamily (TNFRSF10B), also known as TRAIL-R2, TRICK2, KILLER, and CD262. It binds the cytotoxic ligand TRAIL and induces apoptosis. The DR5 receptor is broadly expressed on a variety of normal tissues and many tumors. DR5 expression has been reported to be upregulated in human cells by interferon- alpha, 2-methoxyestradiol, and paclitaxel, and downregulated by adenoviral E3 proteins. |
| Storage: | Store at 4C. Do not freeze. |
| Purity: | Immunogen affinity purified |
| Isotype: | IgG1, kappa |
| Host Name: | Mouse |
| Buffer: | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide. |
| Application Summary: | flow cytometry / FACS analysis |
| Species Summary: | Hu |
| Alternate Names: | anti-TRAIL-R2 antibody, anti-TRAILR2 antibody, anti-KILLER antibody, anti-TRICK2 antibody, anti-TNFRSF10B atniboyd, anti-Ly98 antiboyd, anti-Ly-98 antibody, anti-CD262 antibody |
| Package Size: | 0.1 mg |
| General References: | 1. MacFarlane, M., et al., 1997. J. Biol. Chem. 272:25417. 2. Walczak, H., et al., 1997. EMBO J. 16:5386. 3. Shigeno, M., et al., 2003. Oncogene 22:1653. |
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